世界と中国の高低密度リポタンパク質コレステロールによる不全性脳卒中の負担の比較:傾向と予測
Jiali Zhang1, Mingxiu Liu2, Junlin Yue1
1The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan, China.
Frontiers in neurology
|August 29, 2025
まとめ
高レベルのLDL-Cに関連した脳卒中による死亡率は 特に中国では 年齢基準による死亡率の低下にもかかわらず 増加しています LDL-C管理に重点を置く緊急の公衆衛生戦略は極めて重要です.
科学分野:
- 心血管伝染病学
- 公衆衛生
- ゲロントロジー
背景:
- 血栓性脳卒中 (IS) は,世界中で死と障害の主な原因です.
- 低密度の脂質タンパク質コレステロール (LDL- C) の上昇は,ISの重要な可変リスク因子です.
- 高いLDL-Cに起因するISの負担を理解することは,公衆衛生の介入にとって極めて重要です.
研究 の 目的:
- 1990年から2021年までの高LDL-Cに起因するISのグローバルと中国の負担を評価する.
- 2046年まで高いLDL-Cに関連したIS負担の将来の傾向を予測する.
- 高LDL-CによるIS負担の年齢と性別の格差を分析する.
主な方法:
- IS死亡率と障害調整寿命年 (DALYs) に関するGlobal Burden of Disease (GBD) 2021データベースのデータを使用した.
- 年齢標準化レート (ASR) の時間的な傾向 (APC,AAPC) を評価するJoinpoint回帰.
- 将来の負荷予測にNordpredモデルを適用しました.
主要な成果:
- 2021年には,高いLDL-CによるIS死亡率は,ASMRが減少したにもかかわらず,世界的に43.04%増加し,中国では161.86%増加しました.
- DALYは特に中国 (126.94%) で著しく上昇した.
- 予測によると,ISによる死亡者は2046年までに世界全体で186万人,中国では63万人に達し,中国の死亡率は依然として高い.
結論:
- 人口の老化と成長により,高LDL-CによるISの絶対的な負担は,世界的に,そして中国で増加しています.
- 中国では,LDL-Cに関連したIS率の低下が遅いため,不釣り合いなほど大きな負担に直面しています.
- 効果的なLDL-C管理のための標的化された公衆衛生戦略は,特に中国では緊急に必要とされています.
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