便秘と脳卒中のリスクとの関連: 系統的レビューとメタ解析
Feng Tang1, Tianjun Zhao2, Peiwen Dong1
1Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China.
Frontiers in neurology
|August 29, 2025
まとめ
便秘は脳卒中のリスクを 23% 増加させます このメタ解析では 便秘が 血行性脳卒中の重要な危険因子ですが 血行性脳卒中の危険因子ではありません
科学分野:
- 神経学
- 胃腸内科
- 公衆衛生
背景:
- 便秘は,潜在的全身的な影響を持つ一般的な状態です.
- 脳血管疾患との関連を理解することは 予防戦略にとって極めて重要です
研究 の 目的:
- 便秘と脳卒中のリスクとの関連を体系的に検討し,メタ分析する.
- 脳卒中のサブタイプ (血行性および出血性) に関するこの関連性の潜在的な違いを探求する.
主な方法:
- PubMed,Web of Science,Cochrane Libraryを徹底的に検索した.
- 収録された研究では,便秘患者における脳卒中の調整された効果推定値 (OR,HR,RR) が報告されました.
- ランダム効果モデルがメタ解析に使用され,脳卒中型,地域,研究設計,および性別でサブグループ分析が行われました.
主要な成果:
- 690万人以上の参加者を含む13件の研究が分析されました.
- 便秘は全脳卒中リスクの23%増加と関連していた (OR=1. 23,95%CI: 1. 10~1. 36).
- この関連性は,不全性脳卒中では有意であったが,出血性脳卒中では有意ではなかった. 女性ではリスク増加は認められませんでした.
結論:
- 便秘は不全性脳卒中の危険因子として特定されています.
- これらの発見は 便秘を 潜在的に 改善可能な脳卒中管理の要因として 強調しています
- メカニズムと介入に関するさらなる研究が必要である.
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