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Updated: Sep 9, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

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[3,3]再配置とステレオ制御可能なリング収縮を特徴とする (-) - サイコトリアジンの非対称的総合成

Qingxing Yang1, Hanyi Ouyang1, Haiyong Yu1

  • 1Molecular Synthesis Center & Key Laboratory of Marine Drugs, Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Journal of the American Chemical Society
|August 29, 2025
PubMed
まとめ

研究者は, (-) - サイコトリアジンとテトラヒドロプシコトリアジンの最初の非対称合成を達成しました. 生物学的研究では,前駆体化合物が肝臓X受容体アゴニストとして作用し,アルツハイマー病の薬の開発の可能性を示しています.

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