糖尿病予防プログラムの結果における長期追跡期間における糖尿病発生率と進行に対する両親または一級糖尿病の家族歴の影響

Samuel Dagogo-Jack¹, Erin J Kazemi², Lindsay Doherty²

¹Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN.

Diabetes care

|August 29, 2025

まとめ

家族の糖尿病歴,特に親の糖尿病歴は2型糖尿病のリスクを増大させる. このリスクは部分的に遺伝学によって説明されますが,他の家族や環境要因からも影響を受けます.

科学分野:

内分泌学
遺伝学
公衆衛生

背景:

糖尿病の家族歴は2型糖尿病の危険因子として知られています.
糖尿病予防プログラム (DPP) とそのフォローアップ研究 (DPPOS) は,長期的なリスク要因を調査するためのユニークなデータセットを提供します.

研究の目的:

糖尿病の発生率に対する一級家族歴の影響を調べる.
この関連性における多遺伝子リスクスコア (PRS) の役割を評価する.

主な方法:

DPP/DPPOSの3,072人の参加者を分析し,家族歴のデータと21年の追跡期間を平均しました.
インシデント糖尿病は,アメリカ糖尿病協会の基準を用いて評価された.
人口統計,臨床的変数,DPPランダム化アーム,PRSの調整が行われました.

主要な成果:

糖尿病の家族歴がある場合,糖尿病のリスクが増加する (HR1. 21).
親の糖尿病歴 (PH) は有意な関連性を示し (HR 1. 19),双親の糖尿病歴が最も高いリスクを示した (HR 1. 44).
多遺伝子リスクスコアは,家族歴と糖尿病リスクとの関連の32%を説明した.

結論:

親の糖尿病歴は,DPPの介入グループを考慮しても,2型糖尿病のリスクが増加します.
観察されたリスクはPRSによって部分的に説明され,稀な遺伝的変異,家族,環境要因による貢献を示しています.
これらの発見は,糖尿病前症候群と家族歴のある人の2型糖尿病の複雑な病因を強調しています.

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