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Aging01:26

Aging

179
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
179
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.9K
Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

255
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
255
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

666
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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関連する実験動画

Updated: Sep 9, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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老化に関連した認知低下に対するSRC-1の保護的役割

Hesong Liu1, Yongjie Yang1, Jonathan C Bean1

  • 1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Aging
|August 29, 2025
PubMed
まとめ

ステロイド受容体共活性化剤-1 (SRC-1) は,認知機能低下に対する保護的役割を果たします. SRC-1によるS100カルシウム結合タンパク質A6 (S100A6) の発現を促進することで,年齢に関連した記憶障害を防ぐことができる.

キーワード:
S100A6 についてSRC-1 について老化する認知症

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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科学分野:

  • 神経科学
  • 分子生物学
  • 遺伝学

背景:

  • 肥満と認知症のリスクは強く相関しています
  • ステロイド受容体共活性化剤-1 (SRC-1) は肥満と認知症の両方に関連しています.
  • SRC-1は,細胞プロセスに関与する転写共同活性化剤です.

研究 の 目的:

  • 認知機能と神経変性における SRC-1 の役割を調査する.
  • アルツハイマー病 (AD) に関連するSRC-1のダウンストリーム標的を特定する.
  • SRC-1が神経の可塑性や記憶に影響するメカニズムを明らかにする.

主な方法:

  • SRC-1ノックアウト (SRC-1-KO) マウスのトランスクリプトームを分析するためのRNAシーケンシング (RNA-Seq).
  • SRC-1-KOマウスおよび人間化されたSRC-1変異 (SRC-1L1376P) を有するマウスの認知行動テスト.
  • SRC-1のS100A6遺伝子発現に対する規制効果を評価するプロモータールシフェラーゼアッセイ

主要な成果:

  • SRC-1の喪失はADを含む神経変性疾患に関連する遺伝子発現パターンを変化させた.
  • SRC-1欠乏症は海馬のCA1ニューロンの神経可塑性を低下させた.
  • SRC-1-KOとSRC-1L1376Pの両方のマウスは早期発症の文脈的記憶障害を示した.
  • SRC-1は,S100カルシウム結合タンパク質A6 (S100A6) の発現を有意に促進することが判明した.

結論:

  • SRC-1は,老化に関連した認知機能低下に対する保護的な役割を果たします.
  • SRC-1の保護効果は,S100A6発現を促進することによって媒介される可能性があります.
  • S100A6は,認知機能の文脈でSRC-1によって調節される重要な標的遺伝子として特定されています.