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Updated: Sep 9, 2025

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TNG260は小分子CoREST阻害剤で,STK11変異腫瘍を抗PD-1免疫療法に敏感にする

Leanne G Ahronian1, Soumyadip Sahu2, Minjie Zhang3

  • 1Tango Therapeutics (United States), Boston, MA, United States.

Cancer research
|August 29, 2025
PubMed
まとめ

STK11変異性非小細胞肺がん (NSCLC) は,抗PD-1治療に耐性がある. HDAC1をTNG260で標的にすると,この抵抗性が逆転し,前臨床および臨床試験で抗PD-1の有効性が強化された.

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