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Updated: Sep 9, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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カルボラニルアミノ酸とペプチドの合成のための光触媒分解性B-Cカップリング

Zhenghong Zhou1, Han Ma1,2, Jie Zhou3,4

  • 1Frontiers Science Center for Transformative Molecules, Center for Chemical Glycobiology, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|August 29, 2025
PubMed
まとめ

新しい可視光反応により,ボロン頂部置換のカルボラニルペプチドが合成され,ボロン中性子捕獲療法 (BNCT) のための高度なボロン配送剤が作られ,腫瘍治療が改善されます.

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Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
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