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Updated: Sep 9, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
05:32

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

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新しいキナゾリンハイブリッドの設計,合成,および抗癌評価:DNAインターケレーション,トポイソメラーゼIIα阻害,およびシリコ研究

Rasha A Hassan1, Zeinab Mahmoud1, Ayman Abo Elmaaty2

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Bioorganic chemistry
|August 29, 2025
PubMed
まとめ

新しいキナゾリン混合物は,DNAとトポイソメラーゼIIを標的とした強力な抗がん剤として合成されました. 化合物7は,有意な抗増殖活性を示し,アポトーシスを誘発し,シリコプロファイルで好ましいことを示し,がん治療のための有望なリードとしてマークしました.

キーワード:
アポトーシスDNA インターケレーション分子ドッキング,ADMETキナゾリントポイソメラーゼII

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