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Updated: Sep 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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AAK1を標的とするピラゾロ[1,5-a]ピリミジンベースのマクロサイクルキナーゼ阻害剤の開発

Theresa E Mensing1, Christian G Kurz1, Jennifer A Amrhein1

  • 1Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.

European journal of medicinal chemistry
|August 29, 2025
PubMed
まとめ

新しいピラゾロ[1,5-a]ピリミジンマクロサイクルはNAKキナーゼ,特にAAK1を選択的に抑制し,動物性感染症に対する広範囲の抗ウイルス剤の開発に有望な戦略を提供します.

キーワード:
AAK1 についてウイルス対策BIKE についてキナーゼ阻害剤マクロサイクルNAK について

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

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