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Updated: Sep 9, 2025

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肝臓のサイトクロームP450の神経内分泌の調節は,下垂体におけるパラベントリキュラおよびアーキュア核のN-メチル-D-アスパルテート受容体によって行われます

Renata Pukło1, Ewa Bromek1, Agnieszka Basińska-Ziobroń1

  • 1Department of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.

Drug metabolism and disposition: the biological fate of chemicals
|August 29, 2025
PubMed
まとめ

視床下にあるN-メチル-D-アスパルテート (NMDA) 受容体のGluN2Bサブユニットを阻害すると,肝臓のP450 (P450) 酵素に悪影響を及ぼす. この神経内分泌の調節効果は,薬物の代謝に不可欠であり,臨床実務において考慮されるべきである.

キーワード:
肝臓のサイトクロームP450脳内投与神経内分泌の調節パラベントリキュラーとアーキュア・コアトラクソプロジル (CP-101,606)

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