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Updated: Sep 9, 2025

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

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腫瘍抑制剤DACT3は,Wnt/β-catenin経路を阻害することによって,アパチニブに対するトリプルネガティブ乳がんを感知させる

Jing Wu1, Rui Tian2, Mei Liu1

  • 1Department of Breast Center, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), Chongqing University Cancer Hospital, Chongqing 400030, China.

Translational oncology
|August 29, 2025
PubMed
まとめ

甲酸ベタカテニン3 (DACT3) の分離結合アンタゴニストは,転移性三重陰性乳がん (TNBC) のアパチニブ感受性のバイオマーカーである. DACT3はWnt/β-カテニンのシグナル伝達を阻害することでアパチニブの有効性を高め,TNBCの新たな治療標的となる.

キーワード:
アパチニブ乳がんDACT3 について薬剤耐性Wnt/β-カテニン

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