関連する実験動画

Updated: Sep 9, 2025

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

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Beclin-1はオートファギーを強化し,アポトーシスを阻害し,ペネウス・ヴァナメイのウイルス感染を促進する

Phattarunda Jaree1, Suttipong Tungwaravut2, Chantaka Wongdontri2

  • 1Center of Applied Shrimp Research and Innovation, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.

Fish & shellfish immunology
|August 29, 2025
PubMed
まとめ

カニのベクリン-1は 自己消化と免疫を調節する. Beclin- 1を抑制すると,ウイルスの負荷を減らし,抗ウイルス反応を高めることで,白斑症候群ウイルスに対するエビの生存率を高めます.

キーワード:
アポトーシスオートファジーベックリン-1カニWSSV について

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Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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