1型糖尿病の5~19歳の子供と青年の骨折パターンとアウトカム:米国全国の入院患者サンプルデータ分析,2005~2020年
Kai Yuan Cheng1, Chen Yu Yang1, Shih Chia Liu1
1Department of Orthopedics, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City 10449, Taiwan.
Bone
|August 29, 2025
まとめ
1型糖尿病 (T1DM) の子供と青年は同様の骨折パターンを経験するが,静脈血栓塞栓症 (VTE) と急性腎臓損傷 (AKI) のリスクが高い. この集団における手術前治療の強化の必要性を強調しています
科学分野:
- 小児整形外科
- 内分泌学
- クリティカル ケア 医療
背景:
- 1型糖尿病 (T1DM) と骨折は,子供や青少年において一般的です.
- この集団における骨折パターンとT1DM特異的なアウトカムに関する理解は限られている.
研究 の 目的:
- T1DMとない小児患者の骨折パターンの違いを調査する.
- 子供と青少年における骨折に関連するT1DM特異的アウトカムを特定する.
主な方法:
- 米国全国の入院患者サンプル (NIS) データベースを使用した遡及的観察研究.
- 手足骨折を患った入院児と青少年 (5歳から19歳) の分析
- 295人のT1DM患者と2950人の非T1DM対照群を比較した.
主要な成果:
- T1DMと非T1DMのグループでは,骨折部位の有意な差異は観察されなかった.
- T1DMの子供と青年は,静脈性血栓塞栓症 (VTE) と急性腎臓損傷 (AKI) の確率が高かった.
- 年齢別分析では,T1DMの10~14歳の若者のVTEリスクが増加し,15~19歳の若者のAKIリスクが増加しました.
結論:
- T1DMの小児患者は,T1DMの患者とは類似した骨折パターンを持っています.
- T1DMは骨折後のVTEとAKIのリスクが著しく高まります.
- T1DMに関連した骨折合併症に対する注意深い手術後の管理とさらなる研究の必要性を強調しています.
さらに関連する動画
関連する概念動画
Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
Fractures: Bone Repair
3.7K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.7K
Diabetes: Symptoms, Diagnosis, and Complications
685
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
685
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Insulin: Dosing Regimen and Adverse Effects
253
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
253
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K


