成人におけるアノゲニタルの疫学的,臨床的,経済的負担: 世界的体系的レビュー
Xuedan You1, Stefano Valente2, Dorothy A Machalek3
1Merck & Co., Inc., Rahway, NJ, USA.
まとめ
アノゲニタル (AGW) は一般的なHPV感染です. この見直しでは,特に低所得国における よりよい監視の必要性を強調し,その世界的な流行と発生率を強調しています.
科学分野:
- エピデミオロジー
- 公衆衛生
- ウイルス学
背景:
- ヒトパピローマウイルス (HPV) 感染症によるアノゲニタル (AGW) は公衆衛生上の重大な問題である.
- 拡大するHPVワクチン接種プログラムは,AGWの負荷に関する最新のグローバルデータを必要とします.
研究 の 目的:
- 世界的にアノゲニタルの疫学,臨床的影響,経済的負担を体系的に検討する.
- 国の所得水準,性別,年齢によってAGWデータを分析する.
主な方法:
- 49カ国の187件の研究を体系的にレビューした.
- データはEmbase,MEDLINE,Evidence-Based Medicine Reviews,および会議の議事録 (2013年1月から2023年10月まで) から得られた.
主要な成果:
- AGWの流行率は幅広く変化しました (0.5%~33.1%),発生率は24~2,940例/100,000人/年です.
- 発症率は30代半ば以降に減少したが,すべての年齢層において有意であった.
- 性別,年齢,時間,地域によって 臨床的,経済的負担は異なっていました
結論:
- AGWの流行病学的なデータの大半は,高所得国からのものです.
- AGWの傾向と影響を正確に追跡するために,世界的な監視を強化することが不可欠です.
- 効果的な公衆衛生戦略には AGWの全範囲を理解することが不可欠です.
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