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Updated: Sep 9, 2025

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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Lpar5は,疲労プログラム,生存,NK受容体発現を変化させることで,持続的なウイルス感染に対するCD8T細胞反応を調節する

Marc A D'Antonio1, Brian C Ware1,2, James E DiLisio1

  • 1Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.

Journal of immunology (Baltimore, Md. : 1950)
|August 29, 2025
PubMed
まとめ

リソホスファティド酸受容体5 (LPAR5) のシグナリングは,CD8 T細胞の疲労を調節する. マウスのLPAR5を阻害すると,慢性ウイルス感染症の際にCD8T細胞の生存と機能が向上し,抗腫瘍免疫が改善されます.

キーワード:
CD8 T細胞LCMV についてLPALPAR5 についてT細胞の枯渇

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