多囊性卵巣症候群と急性心筋梗塞と不全性脳卒中の長期的なリスク
Eva Havers-Borgersen1,2, Charlotte Ekelund3,4, Pernille Fog Svendsen5
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
European journal of preventive cardiology
|August 29, 2025
まとめ
多囊性卵巣症候群 (PCOS) の女性は心臓発作や脳卒中のリスクが高くなります. 早期の心血管リスク評価と予防は この集団にとって極めて重要です
科学分野:
- 心臓病科
- 内分泌学
- 生殖 健康
背景:
- 多囊性卵巣症候群 (PCOS) は,生殖年齢の女性の5〜20%に影響します.
- PCOSは心臓血管の危険因子と動脈硬化症に関連しています.
- PCOSにおける動脈硬化性心血管疾患の長期的なリスクは不明である.
研究 の 目的:
- 多囊性卵巣症候群 (PCOS) と動脈硬化性心血管疾患の間の長期的な関連を調査する.
- PCOSの女性における急性心筋梗塞および不全性脳卒中のリスクを決定する.
主な方法:
- デンマーク全国のレジスタリがPCOSと診断された女性 (1995年−2024年) を特定するために使用されました.
- PCOSの女性は年齢とインデックスの年数によって女性対照群と1:4の対照群に匹配された.
- 主なアウトカムは急性心筋梗塞と不全性脳卒中の複合であり,コックス回帰分析が行われました.
主要な成果:
- この研究には,PCOSの女性25,513人と対照群102,052人が参加した.
- PCOSの女性は,心血管の危険因子の有病率が高かった.
- 複合性心血管疾患の25年間の累積発生率は,対照群と比較してPCOSの女性 (3. 4%) で高かった.
- PCOSは,複合性心血管疾患 (調整HR1. 53),急性心筋梗塞 (調整HR1. 58),および不全性脳卒中 (調整HR1. 56) のリスク増加と関連していました.
結論:
- PCOSの女性は,急性心筋梗塞と不全性脳卒中のリスクが増加します.
- 絶対的なリスクが低いにもかかわらず,研究結果は,PCOSの女性の早期心血管リスク評価の重要性を強調しています.
- 多囊性卵巣症候群と診断された女性は予防策を考慮する必要があります.
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