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異なるEAT-Lancetダイエットスコアと亜臨床性動脈硬化症の遵守:ELSA-ブラジルコホート研究の結果
Leandro T Cacau1, Márcio S Bittencourt2, Itamar S Santos2
1Department of Nutrition, School of Public Health, University of São Paulo, Brazil.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 29, 2025
まとめ
この研究では,EAT-Lancetダイエットとサブクリニック性動脈硬化症の間の関連性が見つかりませんでした. EAT- Lancetダイエットに従うことは,冠動脈の結晶化や頸動脈内膜の厚さの進行に有意な影響を及ぼさなかった.
科学分野:
- 心血管疾患の疫学
- 栄養学
- 公衆衛生 栄養
背景:
- EAT-Lancet委員会は,健康と惑星の境界線のための世界的な基準ダイエットを提案しました.
- 健康的な結果と関連しているが,EAT-Lancetダイエットのサブ臨床性動脈硬化症への影響は未調査のままである.
研究 の 目的:
- EAT-Lancetダイエットと亜臨床性動脈硬化症との関連を調査する.
- ブラジルの成人のコホートにおける様々なEAT-Lancetダイエットスコアと動脈硬化症の測定値との関係を評価する.
主な方法:
- 15,105人の参加者 (35歳から74歳) を対象としたブラジルの長距離健康研究 (ELSA-Brazil) のデータを使用した.
- 冠動脈結晶 (CAC) と頸動脈内膜厚さ (cIMT) を経由したサブクリニック性動脈硬化が4年および8年の追跡調査で評価された.
- 4つのダイエットスコア (PHDI,ELDI,WISH,ELS) を用いて,Poisson回帰と線形混合効果モデルで分析した.
主要な成果:
- EAT- LancetダイエットとCACの発生または進行との間に有意な関連性は見つかりませんでした.
- EAT- Lancetダイエットと時間の経過によるcIMTの変化との間に有意な関連性は観察されなかった.
- これらの結果は,モデルの潜在的な混同因子を調整した後でも一貫していました.
結論:
- 心血管疾患 (CVD) のない多くのブラジル人のコホートでは,EAT-Lancetダイエットの遵守は,サブクリニック性動脈硬化症との区別可能な関連を示さなかった.
- この研究では,提案されたEAT-Lancetダイエットは,この集団における亜臨床性動脈硬化マーカーに直接的な影響を与えない可能性があることを示唆しています.
- 異なる集団における潜在的な長期的な効果や関連性を調べるには,さらなる研究が必要である.
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