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Updated: Sep 9, 2025

A High-content Assay for Monitoring AMPA Receptor Trafficking
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Published on: January 28, 2019

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UBE3Aは,タンパク質分解のためのABCA1をターゲットにすることで,泡細胞の形成を促進し,リミエリン化に対抗する

Melanie Loix1,2, Sam Vanherle1,2, Laura Bolkaerts1,2

  • 1Biomedical Research Institute, School of Life Sciences, Hasselt University, Diepenbeek, Belgium.

Nature communications
|August 29, 2025
PubMed
まとめ

発泡性マクロファージは,脱ミエリン性脳疾患において,コレステロールの流出障害により脂質を蓄積する. ATP結合カセットA1 (ABCA1) の分解を防ぐため,ユビキチン-タンパク質E3リガゼA (UBE3A) をターゲットにすることは,中枢神経系の修復のための新しい戦略を提供します.

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