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Updated: Sep 9, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

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単細胞に近い解像度での空間的な長読アプローチは,異なる皮質層および細胞タイプにおけるスプライシングおよびポリアデニレーション部位の発達調節を明らかにする

Careen Foord1,2, Andrey D Prjibelski3, Wen Hu1,2

  • 1Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Nature communications
|August 29, 2025
PubMed
まとめ

新しい空間的なISO形配列 (Spl-ISO-Seq) は,遺伝子調節の研究のためにほぼ単細胞解像度を提供します. この方法では,思春期におけるヒトの視覚皮質における重要な発達のスプライシングとポリアデニレーション部位の変化を明らかにします.

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