関連する実験動画

Updated: Sep 9, 2025

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
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Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

Published on: January 30, 2019

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塩基移位を通じて,暗号的なRNA結合部位を標的とする小分子設計

Lukasz T Olenginski1, Aleksandra J Wierzba1,2, Shawn P Laursen3,4

  • 1Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.

Nature chemical biology
|August 29, 2025
PubMed
まとめ

研究者は,RNA結合小分子をコバラミン (Cbl) に結合することによって改善する新しい戦略を開発しました. この方法は溶解性と特異性を高め,強力なリボスイッチ標的化合物の発見につながった.

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