関連する実験動画
Updated: Sep 9, 2025

05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
1.7K
ディフェニドール水塩化物を含む即時放出錠剤と改定錠剤の製造と評価
Mu-Heng Li1,2, Yuan Zeng2, Wen Lin3
1School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, 442000, China.
Scientific reports
|August 29, 2025
まとめ
ディフェニドール水塩化物 (DPN) の新しい錠剤内製剤は,移動性疾患 (MS) の治療に便利な単回投与を提供します. この革新的な用量形態は 薬剤の即効性と 延期性の両方を提供し 患者の服従性と 治療効果を向上させます
科学分野:
- 医薬品科学
- 薬物投与システム
- 配方開発
背景:
- 運動病 (MS) は,中国で一般的に使用されているディフェニドール水塩化物 (DPN) で,ほとんどすべての人に影響します.
- 従来のDPN錠剤は頻繁に投与する必要があるため,海上旅行などの長期使用は不便です.
研究 の 目的:
- 移動病の管理における便利さと有効性を向上させるため,DPNの新しい錠剤内製剤 (TIT) を開発し,評価する.
- 薬剤の迅速な放出と 延長された放出の両方を 提供する単一投与装置を 作成する.
主な方法:
- 製薬前試験では,フーリエ変換赤外線 (FTIR) と微分スキャニングカロメトリー (DSC) を用いて,薬と補助物質の相互作用を評価した.
- 直接圧縮 (DC) 技術は,放出調節のためにマイクロ結晶セルロース (MCC) とポリエチレン酸化物 (PEO) を使用してコア錠剤を製造しました.
- 応答表面法 (RSM) で,MCCとPEOのインビトロ薬剤放出と腫れ指数への影響を分析し,その後に即時放出シェルでプレスコーティングを行った.
主要な成果:
- PEOの含有量が増加すると DPNの放出が増加し,MCCは放出を抑制した.
- 最適化されたコア錠剤 (100 mg PEO,70 mg MCC) は,腫れ指数52%で12時間で90%の薬剤の放出を達成しました.
- 最終的なTIT製剤は望ましい物理化学的特性,補助物質の含有量の減少,分解時間の短縮を示した.
結論:
- 開発されたDPNの錠剤内製剤 (TIT) は,単一の用量形態から即時および延長された薬剤の放出の両方を成功裏に提供します.
- この新しい薬剤は 移動病の薬剤療法に 便利さと効果を高める有望な戦略です
関連する概念動画
Factors Influencing Drug Absorption: Pharmaceutical Parameters
192
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
192
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
399
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
399
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
1.9K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.9K
Phase I Reactions: Hydrolytic Reactions
252
Hydrolysis, a cornerstone of phase I biotransformation reactions, uses water to cleave chemical bonds. This process is pivotal in drug metabolism, generating more polar metabolites that can be easily excreted.
An important hydrolytic reaction is ester hydrolysis. Ester bonds, often found in prodrugs, are broken down, increasing the solubility of drugs like aspirin and lidocaine for more straightforward elimination. Amide hydrolysis is another critical reaction, targeting amide bonds prevalent...
An important hydrolytic reaction is ester hydrolysis. Ester bonds, often found in prodrugs, are broken down, increasing the solubility of drugs like aspirin and lidocaine for more straightforward elimination. Amide hydrolysis is another critical reaction, targeting amide bonds prevalent...
252
Drug Administration and Therapy Phases: Overview
738
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
738
Prodrugs
2.8K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Prodrugs help overcome...
2.8K

