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Updated: Sep 9, 2025

Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening
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Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening

Published on: January 26, 2024

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次世代のアセチルコレネステラス阻害剤の特定における計算的洞察と実験的突破

Devaraj Hanumanthappa1, Bandral Sunil Kumar1, Sandra Ross Olakkengil Shajan2

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, 560054, Karnataka, India.

Scientific reports
|August 29, 2025
PubMed
まとめ

この研究では,レトロゾールをアルツハイマー病の潜在的な治療法として再利用し,固体脂質ナノ粒子 (L-SLN) に調製した. L-SLNはアルツハイマー病のラットモデルで重要な神経保護性を示し,その治療的可能性を強調した.

キーワード:
アセチルコリンエステラゼアルツハイマー病薬物の再利用レトロゾール固体脂質ナノ粒子

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