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Updated: Sep 9, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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Published on: January 24, 2016

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E3リガゼRAD18は,IFNB1転写を終了するために,リン酸化IRF3を標的とする

Yiting Cai1,2, Jiaqi Zheng1,3, Linlin Zhao1,4

  • 1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China.

Nature immunology
|August 29, 2025
PubMed
まとめ

RAD18は,リン酸化されたIRF3を分解し,タイプIインターフェロンの生成を停止します. この発見はウイルスの感染や自己免疫疾患の 治療対象となる可能性がある.

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