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Updated: Sep 9, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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プリニル化されていないRHO GTPaseシグナリングによって引き起こされるピリン炎症体誘発性関節炎

Murali K Akula1,2, Elisabeth Gilis3,4, Pieter Hertens3,5

  • 1VIB Center for Inflammation Research, VIB, Ghent, Belgium. Naga.Akula@irc.vib-ugent.be.

EMBO molecular medicine
|August 29, 2025
PubMed
まとめ

骨髄細胞におけるゲラニルゲラニルトランスファーゼI (GGTase- I) 欠乏症は,ピリン炎症体を活性化することで重度の関節炎を引き起こす. プレニル化されていないRHO GTPasesは,マクロファージの熱死とIL-1βの放出を引き起こし,炎症を引き起こします.

キーワード:
関節炎プレニル化ピリン炎症体ピロプトーシスRHOファミリー GTPases

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