過去10年間におけるビタミンDスクリーニングとサプリメントの臨床ガイドラインの体系的なレビュー
Judit Zemp1, Cigdem Erol1, Estelle Kaiser1
1Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Archives of public health = Archives belges de sante publique
|August 29, 2025
まとめ
このレビューでは,健康な成人にビタミンDのスクリーニングやサプリメントを推奨するガイドラインは見つかりませんでした. リスクグループについては合意が欠けていますが,ほとんどの場合,骨粗鬆症や高齢者に対して400〜1000IU/日を示唆しています.
科学分野:
- 内分泌学と代謝
- 公衆衛生と疫学
- クリニカル・プラクティスのガイドライン
背景:
- ビタミンDが様々な病気と 関連している証拠が増えており 多くの臨床ガイドラインが 提示されています
- 既存のガイドラインは,ビタミンDのスクリーニングとサプリメントに関する様々な勧告を提供しています.
- ガイドラインを比較し,臨床実践に関するコンセンサスを探す必要がある.
研究 の 目的:
- ビタミンDのスクリーニングとサプリメントの臨床ガイドラインを体系的に比較する.
- 一般的な成人集団と特定のリスクグループに対する勧告を評価する.
- 現在のビタミンDガイドラインのコンセンサスや不一致を特定する
主な方法:
- PubMed,Embase,Cochrane Reviews,およびGoogle Scholar (2013年1月〜2024年6月) の体系的な電子検索を行った.
- ヨーロッパ/北米の成人集団におけるビタミンDスクリーニング/サプリメントに関するガイドラインの追加
- 子供,青少年,妊娠中/授乳中の女性に限ったガイドラインの除外
主要な成果:
- 31のガイドラインが分析され,その3分の2はリスクのある個体に対するスクリーニングを推奨したが,一般の個体に対するスクリーニングは推奨されなかった.
- リスクグループで推奨されるサプリメントの半分で,定義と投与量が異なる (骨粗鬆症/高齢者では400~1000 IU/日).
- リスク因子のない一般の成人のためのスクリーニングやサプリメントを推奨するガイドラインはありません.
結論:
- ビタミンDに関するガイドラインには大きな違いがあり,臨床的コンセンサスを妨げています.
- 一般的な成人ではスクリーニングやサプリメントを推奨するガイドラインはありません.
- 証拠に基づいた標準化された勧告を確立するために,特にリスクのあるグループのために,さらなる研究が必要である.
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