腸内感染症に伴う精神疾患:韓国における全国的なコホート研究
Chaeyoon Kang1, Seung Won Lee2,3,4,5, Hohyun Jung6,7
1Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
まとめ
再発性腸感染症 (IID) は,うつ病や不安症を含む様々な精神疾患を発症するリスクを大幅に高めます. これは腸の健康と 精神疾患の間の 重要なつながりを強調しています
科学分野:
- 胃腸内科と精神科
- 公衆衛生研究
- エピデミオロジー
背景:
- 腸感染症はしばしば一時的なものとして認識されますが,長期的な精神的健康への影響があります.
- 腸-脳軸は 胃腸と神経機能の両方に 影響を与える経路としてますます認識されています
研究 の 目的:
- IIDの再発と精神疾患の発生との関連を調査する.
- 繰り返される腸内感染症に関連した特定の精神疾患を特定する.
主な方法:
- 韓国の国民健康保険局のデータを用いた全国的な遡及コホート研究 (2002年−2013年).
- IIDの診断が3つ以上ある成人と,IIDのない対照群を年齢,性別,健康診断の年に基づいてマッチングする.
- 鬱病,双極性障害,不安障害,強迫性障害,適応障害,有機的精神障害,統合失調症,アルコール使用障害など 8つの精神疾患を調査しました
主要な成果:
- IIDの再発は,うつ病 (aHR,2. 14),双極性障害 (aHR,1. 80),不安障害 (aHR,2. 20),強迫性障害 (aHR,3. 84),適応障害 (aHR,2. 33) および有機精神障害 (aHR,1. 67) のリスクが著しく増加した.
- IIDの頻度が高くなり,精神疾患のリスクが増加した.
- 精神疾患のリスクは特に若い人および男性において高かった.
結論:
- IIDの再発は,潜在的に腸-脳軸の障害と全身の炎症を通して,精神疾患に寄与する可能性があります.
- IIDが再発した患者,特に脆弱なグループでは,精神的健康状態の臨床モニタリングが推奨されます.
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