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Updated: Sep 9, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
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ニューロペプチドY1受容体発現回路は,中枢桃体から脇部下垂体まで,性依存のエタノール消費を調節する

Sophie C Bendrath1, Ashlyn Stone1, Anne M Dankert1

  • 1Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Alcohol, clinical & experimental research
|August 30, 2025
PubMed
まとめ

中枢桃体におけるニューロペプチドYY1受容体 (Y1R) のシグナリングは,特に男性において,特定の神経回路を通じて,酔っぱらったようなエタノール摂取を調節する. これはアルコール使用障害における 性依存神経適応を強調しています

キーワード:
DREADD についてNPY 過剰表現暗闇で飲むニューロペプチドY性別の違い

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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