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Updated: Sep 9, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

650

DRAM1によるVAMP8の安定化は,オートファゴソーム-ライソーム融合を可能にし,転移性エクストラバゼーションを促進する

Rui Zhang1, Vincenzo Torraca2, Chaojun Yan1

  • 1National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.

Autophagy
|August 30, 2025
PubMed
まとめ

DNAダメージ調節されたオートファギー調節器1 (DRAM1) は,VAMP8をリソソームに安定させ,オートファゴソーム-リソソーム融合を促進する. このプロセスは肝細胞癌 (HCC) の転移を促進し,DRAM1を治療標的として示唆しています.

キーワード:
オートファゴソーム-リソソーム融合DRAM1 についてSTUB1 についてVAMP8 についてエクストラバゼーションユビキチネーション

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