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Updated: Sep 9, 2025

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
07:02

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低酸素誘発のPRMT1乳酸化は,腫瘍転移におけるヴィメンチン・アルギニンの非対称性ディメチル化を誘発する

Jia Zhou1, Shuying Qiu1, Xia Yang2

  • 1Department of Medical Oncology, Cancer Center of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 30, 2025
PubMed
まとめ

低酸素はタンパク質アルギニンメチルトランスフェラーゼ1 (PRMT1) の乳化を誘発し,その活性性を高め,ヴィメンチンを改変し,癌の転移を引き起こします. この低酸素- PRMT1- 酵素軸をターゲットにすることで,新種の抗転移戦略が提供されます.

キーワード:
PRMT1 についてアルギニンメチル化癌の転移低酸素ラクチレーションビメンチン

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