[糖尿病前症候群および2型糖尿病患者における代謝機能障害に関連するステアトス性肝疾患]
A N Sasunova1, A A Goncharov1, S V Morozov1,2
1Federal Research Centre of Nutrition, Biotechnology and Food Safety.
Terapevticheskii arkhiv
|August 30, 2025
まとめ
代謝機能障害に関連したステアトス性肝疾患 (MASLD) の患者では,炭水化物の代謝障害が肝臓の健康を悪化させる. 2型糖尿病 (DM) は,より重度の肝繊維症と関連しており,病気が進行していることを示しています.
科学分野:
- ヘパトロジー
- 内分泌学
- 代謝障害
背景:
- 代謝機能障害に関連した脂肪性肝疾患 (MASLD) は,健康上の懸念が高まっている.
- MASLDの進行における糖尿病前症候群や2型糖尿病 (DM) などの炭水化物代謝障害の役割については,さらなる調査が必要である.
- 代謝の健康と肝臓疾患の重度の相互作用を理解することは,患者の管理に極めて重要です.
研究 の 目的:
- MASLD患者におけるステアトーシスおよび肝繊維症の流行を決定する.
- MASLD,ステアトーシス,線維症,炭水化物代謝障害 (糖尿病前症,DM) の関連性を分析する.
主な方法:
- 4101人の患者の記録を遡って分析した.
- 肝臓ステアトーシスと繊維症の評価のために,制御された衰弱パラメータ (CAP) による振動制御のトランジントエラストグラフィー.
- 糖尿病前症候群のないMASLD,糖尿病前症候群のMASLD,糖尿病前症候群のMASLDに分類された.
主要な成果:
- 重度の肝硬変 (S3) の罹患率は,前糖尿病とDM群 (約. これらの障害のないグループ (61. 9%) よりも高かった.
- 中度から重度の肝繊維症 (F2- F4) は,糖尿病前症候群 (34. 0%) と糖尿病前症候群 (45. 4%) の患者で,糖尿病前症候群 (24. 1%) の患者と比較してより一般的であった.
- 代謝機能障害に関連したステア肝炎の罹患率は,前糖尿病と糖尿病前糖尿病のグループ (約. 34-35%),これらの障害のないグループでは著しく低い (26. 7%).
結論:
- 炭水化物代謝障害は,MASLDにおける脂肪酸症および肝繊維症の増加と強く関連しています.
- ステアトーシスの重症度は前糖尿病とDM群では異なっていなかったが,2型DMは進行性肝繊維症の最も高い罹患率と関連していた.
- これらの発見は,MASLDの進行と線維症の発達に対する血糖制御の重要な影響を強調しています.
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