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フロロピリミジン治療の最適化:重度の毒性率に対するDPYD遺伝子型ベースの投与の現実的な影響

Anouk H E van Kan1, Ankie M Harmsze1, Karin Herbschleb2

  • 1Department of Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, The Netherlands.

British journal of clinical pharmacology
|August 30, 2025
PubMed
まとめ

DPYDの遺伝子型によるフッ素ピリミジン投与は,変異のキャリアとワイルドタイプの患者で同様の重度の毒性率を示した. 個々の用量の定位は,特にC.1236G>Aキャリアの場合,安全性を最適化するために極めて重要です.

キーワード:
DPDの欠陥DPYDフロロピリミジン遺伝子型決定薬剤遺伝学

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