モンキーポックス (以前はモンキーポックス) の世界的なおよび地域的な死亡率統計:包括的なシステマティックレビューとメタ解析
Srivatsa Surya Vasudevan1, Tiba Yamin Kandrikar2, Prachi Cooner3
1Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Pathogens and global health
|August 30, 2025
まとめ
マポックスウイルス (MPXV) の死亡率は,特にCOVID後および流行地域では,世界的に減少しています. しかし,HIVに感染した人は特に高いmopox死亡リスクに直面しており,標的型の介入が必要である.
科学分野:
- エピデミオロジー
- 感染症
- 公衆衛生
背景:
- 世界的にMpoxウイルス (MPXV) の死亡傾向はよく定義されていません.
- 公衆衛生の介入と 資源の配分に際して 麻疹による死亡率を理解することは 極めて重要です
研究 の 目的:
- 世界と地域におけるポキソナウイルスによる死亡率を 体系的に評価する.
- 異なる地理的場所と時間帯におけるポークスの死亡率の分層化を分析する.
- HIVの共感染を含む,mpoxによる死亡率に影響を与える要因を特定する.
主な方法:
- モポックスによる死亡率を報告した研究の包括的な体系的レビューとメタ解析.
- 2025年6月までのPubMed,Embase,Scopus,Web of Scienceのデータベースを検索しました.
- ランダム効果の比例メタ分析,感度分析,メタ回帰を用いた.
主要な成果:
- 総合的なmopox死亡率は3.1%で,時間の経過とともに有意な減少が見られた (2016年以前の11.4%からCOVID後の1.5%).
- 死亡率はHIV共感染者 (83. 8%) で顕著に上昇し,地域によって異なる (アフリカで最も高い6. 3%,ヨーロッパで最も低い0. 1%).
- 出版年数は死亡率の減少の重要な予測因子であり,改善した結果を示した.
結論:
- 世界的なmopox死亡率は時間とともに減少しており,COVID後期にはさらに減少した.
- HIV共感染者は緊急に標的を絞った介入を必要とする高リスクグループです.
- 地理的な差異は依然として存在し,地域特有の公衆衛生戦略の必要性を強調しています.
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