妊婦の乳がんに対する葉酸サプリメントの投与量:国際専門家の勧告と現在の慣行に関する調査
Yi Li1, Rebecca Bromley2, Kimford J Meador1
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
まとめ
専門家は,妊娠中の患者に対して,1〜2mgの葉酸を毎日摂取することを推奨し,しばしば特定の薬剤と個人のニーズに基づいて投与量を調整します. これは個別化されたサプリメント戦略への移行を反映しています
科学分野:
- 神経科学
- 産婦人科
- 薬理学について
背景:
- 葉酸のサプリメントは,神経管の欠陥を軽減し,妊娠中の神経発達の結果を改善するために不可欠です.
- 妊娠中の患者にとって最適な葉酸の投与量は,様々な影響因子により不明である.
- 現在のガイドラインは,推奨される葉酸の投与量 (0. 4~5 mg/日) を幅広く提供しています.
研究 の 目的:
- 妊婦のエピレプシー患者における葉酸サプリメントの投与量に関する現在の臨床実務と推奨事項について専門家を調査する.
- この集団における葉酸投与に関する専門家の推薦に影響を与える要因を理解する.
主な方法:
- 閉経コンソーシアムを通じて,産児期のの専門家に国際調査が配布されました.
- この調査は,妊婦のエピレプシーに対する葉酸補給の実践と勧告に関する公開回答を集めました.
- 反応は,投与範囲と特定の臨床シナリオによって分類された.
主要な成果:
- 調査対象の専門家の大多数は (73.1%) 葉酸の投与量を1〜2mg/日と推奨した.
- 特にバルプロアートまたは酵素誘発抗発作薬を使用している患者では,42. 3%が個別の投与戦略を推奨した.
- 1 mgの葉酸を単独または産前ビタミンと併用して摂取することが推奨されています.
結論:
- 国際的な専門家のコンセンサスは,妊婦の epilepsy 患者に対して1〜2 mg/dayの葉酸補給を好みます.
- 以前より高い用量から離れ,個別化された葉酸用量戦略に注目される傾向があります.
- 専門家の推薦は,この患者群で最適な葉酸の投与量を決定する際の複雑さを強調しています.
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