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Updated: Sep 9, 2025

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AT1受容体は,周周脂肪組織におけるiNOS発現を増加させることで,セプシス誘発の血管性麻痺に作用する

Wanessa M C Awata1, Gustavo F Pimenta1, Thales M H Dourado1

  • 1Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.

Pflugers Archiv : European journal of physiology
|August 30, 2025
PubMed
まとめ

セプシスは,血管内脂肪組織 (PVAT) の窒素酸化物 (NO) 産生を増加させるアンジオテンシンII型1受容体 (AT1R) を活性化することによって,血管の過敏反応を引き起こす. ロサルタンでAT1Rを阻害すると,セプシス誘発の機能障害が予防されます.

キーワード:
AT1受容体INOS について周血管脂肪組織レニン・アニオテンシン・アルドステロン系セプシス血管損傷

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