関連する実験動画

Updated: Sep 8, 2025

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

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妊娠8~20週間のヒト胎児臓のβおよびα細胞におけるプロホルモンコンバーターゼ1/3の分布

Yu S Krivova1, A E Proshchina2, O S Godovalova2

  • 1Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia. homulkina@gmail.com.

Bulletin of experimental biology and medicine
|August 30, 2025
PubMed
まとめ

開発中のヒト臓β細胞は,プロホルモンコンバーターゼ1/3 (PC1/3) をインスリン生成前に蓄積する. 成熟したβ細胞は,分化時に一時的にグルカゴンを発現する.

キーワード:
グルカゴン人間開発インスリン臓プロホルモンコンバーターゼ 1/3 (PC1/3)

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Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
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