Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Crossing Over01:34

Crossing Over

147.9K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
147.9K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

5.9K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.9K
Polytene Chromosomes02:04

Polytene Chromosomes

10.2K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.2K
Meiosis I01:49

Meiosis I

194.4K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
194.4K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

5.7K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
5.7K
Cohesins02:20

Cohesins

4.7K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
4.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Comparative induced pluripotent stem cell models of young, aged, and progeroid, as a resource to study human aging trajectories.

Stem cell research·2026
Same author

Antenatal discovery of mosaic trisomy 14 in an early-onset malformative syndrome.

Molecular cytogenetics·2026
Same author

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.

Nature genetics·2026
Same author

Hypertrophic Cardiomyopathy as a Key Feature of MRAS-Related Noonan Syndrome: New Case and Comprehensive Literature Review.

Prenatal diagnosis·2026
Same author

DNA methylation episignature for Smith-Magenis and Potocki-Lupski syndromes: a mirror perspective.

European journal of human genetics : EJHG·2025
Same author

Systematic analysis of snRNA genes reveals frequent <i>RNU2-2</i> variants in dominant and recessive developmental and epileptic encephalopathies.

medRxiv : the preprint server for health sciences·2025
Same journal

Isolation of Mesenchymal Stem Cell-Derived Extracellular Vesicles.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Modeling Melanoma Immune Surveillance by CAR-T Cells in Human Skin Organoids.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Stepwise Optimization of a Matrigel-Based In Vitro Angiogenesis Assay for Reproducible and Quantifiable 2D-Tube Formation Using HUVECs.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Quantifying Mechanical Properties of Fresh Ovarian Tissue with Optical Brillouin Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

3D Chromatin Architecture During Early Development: New Methods and New Findings.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Metabolic Plasticity in Embryogenesis Throughout the Lens of NAD<sup></sup>.

Methods in molecular biology (Clifton, N.J.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: Unraveling the Dynamics of Eukaryotic DNA Replication Through Single-Molecule Visualization
07:37

Author Spotlight: Unraveling the Dynamics of Eukaryotic DNA Replication Through Single-Molecule Visualization

Published on: September 27, 2024

1.7K

クロモトリプシス

Franck Pellestor1,2, Benjamin Ganne3,4, Vincent Gatinois3,4

  • 1Unit of Chromosomal Genetics and Research Platform Chromostem, Department of Molecular Genetics and Cytogenomics, Site Unique de Biologie (SUB), Montpellier CHU, Montpellier Cedex 5, France. f-pellestor@chu-montpellier.fr.

Methods in molecular biology (Clifton, N.J.)
|August 30, 2025
PubMed
まとめ
この要約は機械生成です。

クロモトリプシスは複雑なゲノム再編成の一種で,大量に染色体の断片化と再組みを伴う. 種間で観察されるこの現象は,急速なゲノム進化を促し,種種化を説明する可能性がある.

キーワード:
中絶性アポトーシス癌についてクロマチンブリッジ染色体分離ミスクロモトリプシス進化についてゲノム不安定性マイクロ核

さらに関連する動画

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

14.1K
Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
10:39

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II

Published on: February 26, 2018

15.7K

関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: Unraveling the Dynamics of Eukaryotic DNA Replication Through Single-Molecule Visualization
07:37

Author Spotlight: Unraveling the Dynamics of Eukaryotic DNA Replication Through Single-Molecule Visualization

Published on: September 27, 2024

1.7K
Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

14.1K
Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
10:39

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II

Published on: February 26, 2018

15.7K

科学分野:

  • ゲノミクス
  • 分子生物学
  • 進化生物学

背景:

  • クロモトリプシスは複雑なゲノム再編成であり,2011年に特定され,現在はクロモアゲネシスに分類されています.
  • この現象は様々な状態で起こります がんや先天性疾患など 様々な種で健康な個体でも起こります

研究 の 目的:

  • クロモトリプシスを他の複雑な再配置から区別する分子特性を特徴づける.
  • クロモトリプシスを駆動する細胞メカニズムとゲノム再編成におけるその役割を解明する.

主な方法:

  • クロモトリプシスを定義する分子特性の分析
  • クロモトリプシスにつながる細胞イベントのカスケードを詳細に示す実験モデルのレビュー.

主要な成果:

  • 染色体トリプシスは特定の分子シグネチャーによって特徴付けられ,他の複雑な染色体再配置と区別されます.
  • クロモトリプシスは主に3つのメカニズムから始まります 微核の形成,テロメア結合によるクロマチンの橋渡し,中断性アポトシスです
  • これらのプロセスは,損傷した染色体物質の断片化,修復,伝播を含みます.

結論:

  • クロモトリプシスは高解像度ゲノム解析による重要な発見であり,急速なゲノム改変のメカニズムを明らかにしています.
  • マクロ進化と種の概念を支える ゲノム変異の発生と初期発達において 決定的な役割を果たしている.