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関連する概念動画

Channel Rhodopsins01:11

Channel Rhodopsins

2.6K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
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Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Photochemical Electrocyclic Reactions: Stereochemistry01:26

Photochemical Electrocyclic Reactions: Stereochemistry

1.9K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
1.9K
Color Vision01:24

Color Vision

695
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
695
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.6K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.6K
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

9.4K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
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Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

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クロモプレキシ

Franck Pellestor1,2, Jean Baptiste Gaillard3, Benjamin Ganne3,4

  • 1Unit of Chromosomal Genetics and Research Platform Chromostem, Department of Molecular Genetics and Cytogenomics, Site Unique de Biologie (SUB), Montpellier CHU, Montpellier Cedex 5, France. f-pellestor@chu-montpellier.fr.

Methods in molecular biology (Clifton, N.J.)
|August 30, 2025
PubMed
まとめ
この要約は機械生成です。

クロモプレキシは 複雑な染色体の再編成で 遺伝子の融合と癌の障害を 引き起こします この巨大なゲノムイベントは 腫瘍発生の初期に発生し 腫瘍の進化と進行を促します

キーワード:
クロモアゲネシスクロモプレキシ削除する遺伝子融合前立腺がん断続的な進化トランスロケーション腫瘍

さらに関連する動画

High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon

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Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
12:47

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

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関連する実験動画

Last Updated: Sep 9, 2025

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
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High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon

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Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
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Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

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科学分野:

  • ゲノミクス
  • 癌 生物学
  • 分子腫瘍学

背景:

  • クロモプレクシーは複数の染色体を含む複雑なゲノム再編成です.
  • これは前立腺がんを含む様々な癌で観察された 遺伝子融合と破壊につながります
  • 染色体形成の正確なメカニズムはほとんど不明である.

研究 の 目的:

  • 染色体形成の背後にあるメカニズムを解明する.
  • 腫瘍形成と腫瘍の進行における 染色体の役割を理解するためです
  • クロモプレキシに関連したゲノム構成を調べる

主な方法:

  • 癌ゲノムにおける複雑な染色体の再編成の分析
  • 特定のゲノム状況における二重鎖断裂パターンの特定
  • 染色体間および染色体内転位および切除の特徴づけ

主要な成果:

  • クロモプレキシは,重要な複製数変化なしに広範囲にわたる染色体の再配置を含みます.
  • これらの再編成は オープンクロマチンや活性転写のような 特定のゲノム構成と関連しています
  • 染色体は癌の初期に発生し,クローン進化に寄与する.

結論:

  • 染色体はガンにおける ゲノム不安定性の重要な要因です
  • 急速なゲノム変化による 断続的な腫瘍の進化モデルを サポートしています
  • クロモプレキシのメカニズムを完全に理解し,潜在的にターゲットにするためにさらなる研究が必要です.