Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

5.7K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
5.7K
Chromosome Structure02:40

Chromosome Structure

23.4K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
23.4K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

5.9K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.9K
Crossing Over01:30

Crossing Over

4.7K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
4.7K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

8.0K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
8.0K
Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

11.2K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
11.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Biological maturation drives the hepatic-to-renal switch in erythropoietin production at birth.

EBioMedicine·2026
Same author

CNV-Hub: an integrated web-based platform for CNV classification and interpretation using multi-algorithm consensus.

NAR genomics and bioinformatics·2026
Same author

Phenotypic description of a large French series of individuals with Potocki-Lupski syndrome.

Journal of medical genetics·2026
Same author

Detection of a Distinct Erythropoietin (EPO) Profile After Isoelectric Focusing in Patients With Familial Erythrocytosis.

Drug testing and analysis·2026
Same author

9q34.11 Microduplications Encompassing SET Gene Are Associated With Neurodevelopmental Disorder and Recurrent Dysmorphisms.

American journal of medical genetics. Part A·2025
Same author

Exome sequencing in severe non-syndromic specific learning and language disorders in a French cohort.

Molecular autism·2025
Same journal

Isolation of Mesenchymal Stem Cell-Derived Extracellular Vesicles.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Modeling Melanoma Immune Surveillance by CAR-T Cells in Human Skin Organoids.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Stepwise Optimization of a Matrigel-Based In Vitro Angiogenesis Assay for Reproducible and Quantifiable 2D-Tube Formation Using HUVECs.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Quantifying Mechanical Properties of Fresh Ovarian Tissue with Optical Brillouin Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

3D Chromatin Architecture During Early Development: New Methods and New Findings.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Metabolic Plasticity in Embryogenesis Throughout the Lens of NAD<sup></sup>.

Methods in molecular biology (Clifton, N.J.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Sep 9, 2025

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation
21:55

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation

Published on: April 30, 2012

30.8K

人工知能とクロモトリプシス

Davide Callegarin1, Nada Maaziz1, Anne-Laure Mosca1

  • 1Laboratoire de Génétique Chromosome et Moléculaire, équipe DIAD (Développement de l'Intelligence artificielle au CHU de Dijon), CHU Dijon, France.

Methods in molecular biology (Clifton, N.J.)
|August 30, 2025
PubMed
まとめ
この要約は機械生成です。

人工知能 (AI) は複雑なゲノム再編成であるクロモトリプシスを検出し理解するための新しい方法を提供します. 機械学習とディープラーニングを含むAIは,より良い遺伝子研究と臨床アプリケーションのためのゲノムデータの分析を改善します.

キーワード:
人工知能クロモトリプシス全ゲノムシーケンシング

さらに関連する動画

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
08:24

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion

Published on: July 27, 2021

1.5K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.8K

関連する実験動画

Last Updated: Sep 9, 2025

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation
21:55

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation

Published on: April 30, 2012

30.8K
Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
08:24

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion

Published on: July 27, 2021

1.5K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.8K

科学分野:

  • ゲノミクス
  • バイオ情報学
  • コンピュータ生物学

背景:

  • クロモトリプシスは複雑なゲノム再編成を含み,カリオタイプ化,FISH,アレイ-CGH,NGSなどの伝統的な検出方法に課題を投げかけています.
  • クロモトリプシスの正確な検出と解釈は,様々な疾患におけるその役割を理解するために不可欠です.

研究 の 目的:

  • クロモトリプシスの検出と特徴付けにおける人工知能 (AI) の可能性を探る.
  • 複雑なゲノムデータを分析する際に AI が従来の方法の限界を克服する方法を強調する.

主な方法:

  • 機械学習とディープラーニングアルゴリズムを使用して 複雑なゲノムデータセットを分析します
  • クロモトリプシスの総合的な理解のためにマルチオミクスデータを統合する.
  • クロモトリプシスのAIアプリケーションのケーススタディと最近の進歩をレビューします.

主要な成果:

  • AIは繰り返し発生するパターンを特定し,高精度でクロモトリプシスの機能的結果を予測する可能性を示しています.
  • AIは多様なゲノムデータの統合を容易にし,クロモトリプシスの包括的な分析を強化します.
  • 人工知能のツールは,染色体トリプシスの検出と特徴づけの精度と効率を向上させることを約束しています.

結論:

  • AI 特に機械学習とディープラーニングは クロモトリプシスの研究に大きな進歩をもたらしています
  • ゲノミクスにおける AI アプリケーションは,染色体トリプシスとその臨床的影響をよりよく理解するのに役立ちます.
  • AIは遺伝子研究と医学に 革命を起こそうとしています 特に複雑なゲノム再編成を 分析する分野です