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Updated: Sep 9, 2025

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ATXN2フォスフォコードの解読:疾患における構造的洞察と治療的機会

Apoorva Pai Kalasa Anil Kumar1, Suhail Subair1, Prathik Basthikoppa Shivamurthy1

  • 1Yenepoya University, Mangalore, India.

The protein journal
|August 30, 2025
PubMed
まとめ

この研究では,アタキシン-2 (ATXN2) の重要なリン酸化部位をマッピングし,その調節がRNA代謝にどのように影響し,脊椎小脳性アタキシア2型 (SCA2) やアミオトロフィック横筋硬化症 (ALS) や癌などの神経退行性疾患に寄与するかを明らかにした.

キーワード:
アミオトロフィック・ラテラル・スクレロスアタクシン-2ファスフォプロテオミクススピノセレベラアタキシア タイプ2

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