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Updated: Sep 9, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
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An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

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合成,結晶構造,およびα-グルコシダース阻害体としての新しい2,4-チアゾリジンダイオン混合体のインビトロ評価

Abhik Paul1, Arnab Sarkar1, Sai Satyaprakash Mishra1

  • 1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.

Future medicinal chemistry
|August 30, 2025
PubMed
まとめ

新しいVD- TZDハイブリッドは,2型糖尿病 (T2DM) の治療において強力なアルファ- グルコシダース抑制 (AGI) を示しています. 化合物6fは有望な有効性と安全性を示し,主要なAGI候補としてさらなる開発を正当化しています.

キーワード:
2,4-チアゾリジンジオンアドメット結晶学的な検証分子ドッキング構造・活動関係ベラトラルデヒドα-グルコシダース抑制

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