ナンチュアン鶏の筋肉内脂肪の蓄積を制御する重要な遺伝子と生化学的特徴

Naiyi Xu¹, Zhengfu Feng², Feifan Chen²

¹College of Animal Science and Technology, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China.

Poultry science

|August 30, 2025

まとめ

この研究では,年配の南川鶏の筋肉内脂肪 (IMF) の蓄積に影響を与える重要な要因を明らかにし,鶏の質を改善するためにIMF形成に関与する特定の脂肪酸と遺伝子を特定しました.

科学分野:

動物科学
生物化学
遺伝学

背景:

筋肉内脂肪 (IMF) は鶏肉の品質に大きく影響しますが,老鶏の脂肪の蓄積はあまり研究されていません.
南西中国の二重用鶏は肉の味と品質で高く評価されています

研究の目的:

熟成した南川鶏のIMFの生物化学的特徴と規制メカニズムを体系的に調査する.
この種のIMF蓄積に関連する遺伝子を特定する.

主な方法:

屠殺の性能,IMF,トリグリセリド (TG),フォスフォリピド (PLIP),総コレステロール (TCHO),乳筋の脂肪酸 (FA) 含有量の測定
差異的に発現する遺伝子 (DEGs) を識別し,規制経路を探求するためのRNA配列決定.
タンパク質とタンパク質の相互作用 (PPI) ネットワーク分析で,IMFの堆積と遺伝子の関連性を検証する.

主要な成果:

IMFの含有量が高くなると,肉体の収穫量とTGのレベルが増加したが,切断力が低下した.
4つの特定の脂肪酸 (C20: 1n10,C20: 4n6,C22: 5n6,C22: 6n3) は,高いIMF群で著しく高かった.
配列解析により,ECM受容体相互作用,アクチン細胞骨格,および焦点結合経路で濃縮された469のDEGが特定されました. THBS1,THBS2,ITGA2,ITGA9,ITGAV,LUMのような遺伝子はIMFの預金と関連していた.

結論:

この研究は,長寿の南川鶏におけるIMFの堆積の生化学的基礎と遺伝的調節を解明する.
特定された遺伝子は,鶏肉の質とIMFの含有量を向上させるための遺伝子改良戦略の基盤を提供します.

キーワード:

熟した南川鶏筋肉内脂肪 RNAシーケンシング制御遺伝子

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