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Updated: Sep 9, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
09:45

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Published on: January 29, 2018

9.5K

SUMO E1共性アロステリック阻害剤は,MAT2A-AdoMetDC軸経由でポリアミン合成を上位調節する

Shuai Zhang1, Jinzhu Li1, Zhiying Wang1

  • 1Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Wuhan 430068, China; Hubei Key Laboratory of Industrial Microbiology, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.

Bioorganic chemistry
|August 30, 2025
PubMed
まとめ

新しいSUMO E1共性アロステリック阻害剤 (CAI) を特定し,タンパク質SUMOylationを妨害し,意外にポリアミンの合成を促進しました. これらのCAIとポリアミン阻害剤を併用すると,がん細胞に対する相乗効果が見られます.

キーワード:
コバルントアロステリック阻害剤メチオニンアデノシルトランスフェラーゼポリアミンスカードック小型ユビキチン型変形剤

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