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Updated: Sep 9, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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アルツハイマー病の治療に伴う抗神経炎症活性を持つ高度に選択的なBChE阻害剤の発見

Yarong Zhao1, Kun Wu1, Wei Luo1

  • 1School of Pharmaceutical Science, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.

European journal of medicinal chemistry
|August 30, 2025
PubMed
まとめ

新しい化合物であるN14は,神経保護と認知の利点を提供するブチリルコリネステラーゼ (BChE) の強力で選択的な阻害を示しています. このBChE阻害剤は,アルツハイマー病 (AD) の多機能治療薬として有望であることを示しています.

キーワード:
アルツハイマー病炭酸塩高度に選択的なBChE阻害剤神経炎症性

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