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イタリア北西部のコホートにおける出生体重と成人期の死亡率との関連
Lorenzo Milani1, Elena Farina2, Paola Armaroli3
1Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy.
Public health
|August 30, 2025
まとめ
低出生体重は,すべての原因と心血管疾患による成人死亡のリスクを高めます. このリスクは性別であり,女性の心血管疾患と男性の神経系疾患に影響します.
科学分野:
- 公衆衛生
- 流行病学
- 縦断的な研究
背景:
- 世界的に見ると 新生児の約15%が 体重不足で 長期的な健康リスクが伴います
- 低出生体重は心臓血管疾患を含む様々な原因による死亡率の増加と関連しています
- 高い出生体重は 癌などの特定の疾患のリスクの増加とも関連しています
研究 の 目的:
- 出生体重と成人の死亡率との関連を調査する.
- 総合的な分析のために,トリノの縦断研究 (TLS) のデータを活用する.
主な方法:
- トリノ長期研究 (TLS) の健康管理コホート解析
- 1920年代に生まれた2992人を含め,1971年から2013年まで追跡した.
- 生まれた時の体重 (<2500g, <2800g, ≥4000g) と死因,心血管,癌,呼吸器,神経系,消化器疾患の評価は,生存率と競合するリスクモデルを用いて行われます.
主要な成果:
- 低出生体重 (<2500gまたは<2800g) は,あらゆる原因による死亡の重要な危険因子として現れました.
- 低出生体重は心臓血管疾患による死亡リスクの増加と関連していました.
- 性別別別分析により,低出生体重は女性における心血管疾患による死亡率と男性における神経系疾患による死亡率に関連していることが明らかになった.
結論:
- 低出生体重は 成人の死亡率の重要なリスク因子で 心血管や神経系疾患などの全ての原因と特定の疾患を 包含しています
- 発見は,非正常な出生体重に対処し,長期的な健康結果を軽減する重要性を強調しています.
- 低出生体重の発生率を減らすための公衆衛生政策の必要性を強調しています.
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