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Updated: Sep 9, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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イブプロフェンとピペリドンのハイブリッド分子:抗癌薬の開発に向けた合理的なアプローチ

Siva S Panda1, Walid Fayad2, Ahmed A F Soliman2

  • 1Department of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Bioorganic & medicinal chemistry
|August 30, 2025
PubMed
まとめ

新種のクルクミンにインスパイアされたハイブリッド分子は 強力な抗がん作用を示し,腫瘍の成長を効果的に抑制し,細胞死を誘発します. 化合物7bはメラノーマモデルにおいて優れた有効性を示し,その治療的可能性を強調した.

キーワード:
3,5-ビス (イリデン) -4ピペリドン核拡散防止イブプロフェンMDM2 について分子モデリング

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