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Updated: Sep 9, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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Sidt2は,p65シグナル伝達による自死流を促進することによって,TNF-α誘発のアポトーシスと炎症を緩和する

Biao Li1, Leilei Wang1, Gengming Zhang1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

International immunopharmacology
|August 30, 2025
PubMed
まとめ

この研究では,Sidt2 (RNA干渉欠陥-1 経膜ファミリーメンバー2) の発現がアピカル歯周炎 (AP) で低下することが示されました. 低レベルのSidt2は,オートファギーを阻害し,p65シグナリングを活性化することで,炎症とアポトーシスを悪化させる.

キーワード:
オートファジー細胞死歯科セメントリンソーム膜タンパク質歯周病信号変換

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