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Updated: Sep 9, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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シクロスポリンA代謝の主要な調節体としての肝臓のクリュッペル型因子15の暴露と有害作用

Xiaohua Guo1, Bingxia Wen2, Shilin Li3

  • 1Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China; Department of Hepatobiliary Surgery, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, Anhui, China.

Drug metabolism and disposition: the biological fate of chemicals
|August 30, 2025
PubMed
まとめ

クリュッペルのような因子15 (KLF15) はサイクロスポリンA (CsA) の解毒を抑制し,臓器損傷を引き起こす. KLF15を阻害すると,CsA代謝が促進され,CsA誘発の肝臓内毒性が予防または逆転し,新たな治療戦略が提供されます.

キーワード:
サイクロスポリンA薬物の代謝クリュッペルのような因子 15肝臓と腎臓の損傷

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