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Updated: Sep 9, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

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アルド・ケト・リドゥクタゼ1C3による窒素還元によるフルニトラゼパムの代謝活性化

Cátia F Marques1, Maya Narang2, Kim A Sharp2

  • 1Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Drug metabolism and disposition: the biological fate of chemicals
|August 30, 2025
PubMed
まとめ

アルド・ケト・リドゥクタゼ1C3 (AKR1C3) はフルニトラゼパムを反応性の中間物質に代謝し,薬物毒性を増加させる可能性があります. フルニトラゼパムはまた,AKR1C2を阻害し,神経活性ステロイドの産生に影響し,AKR1C3とAKR1C2がフルニトラゼパムの反応に影響することを示唆しています.

キーワード:
アルド・ケト・リドゥクタゼ薬物の代謝ヘパトーム細胞マススペクトロメトリー

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