血清25ヒドロキシビタミンDの低下は,過体重/肥満の個人に重度の代謝機能障害に関連した脂肪性肝疾患と関連している:横断的な研究
Yan Li1, Minglan Yang1, Jiang Yue1
1Department of Endocrinology and Metabolism, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nutrition research (New York, N.Y.)
|August 30, 2025
まとめ
低ビタミンDレベルは,過体重や肥満の個体において,より重度の肝臓脂肪含有量に関連しています. 十分なビタミンDを摂取すると,代謝機能障害に関連した脂肪性肝疾患 (MASLD) のリスクが低下する可能性があります.
科学分野:
- 内分泌学
- ヘパトロジー
- 栄養学
背景:
- ビタミンDの状態と代謝機能障害に関連した脂肪性肝疾患 (MASLD) の関連性は完全に理解されていません.
- MASLDにおけるビタミンDと腹部脂肪の分布の関係に関する研究は限られている.
- 過体重と肥満はMASLDの重要な危険因子です.
研究 の 目的:
- 血清ビタミンDが過体重/肥満の集団における肝臓脂肪含有量 (LFC) の重症度と逆に関連しているという仮説を検証する.
- ビタミンDの状態と腹部脂肪の分布,皮下および内臓脂肪組織,および臓脂肪の関係を調べる.
主な方法:
- 201人の体重過多/肥満患者 (BMI ≥23 kg/ m2) は,25-ヒドロキシビタミンD (25(OH) D濃度 (欠乏症 < 20 ng/ mL 対正常値 ≥20 ng/ mL) によって分類された.
- 磁気共鳴画像 - 陽子密度脂肪分子は,肝臓,臓,腹部 (皮下および内臓) の脂肪を定量化した.
- 関連性を評価するために,多変数調整されたロジスティック回帰を含む統計的分析が行われました.
主要な成果:
- ビタミンD欠乏症の個人は,正常なビタミンDレベル (P < .05) に比べて,LFCと皮下脂肪組織 (SAT) が有意に高かった.
- グループ間で内臓脂肪組織や臓脂肪の有意な差は認められなかった.
- LFCとSATの重度の上昇は,血清25[OH]D濃度の低下と相関する (P < .05). 25 ((OH) D) の最高位にある個体は,重度の肝硬変の確率が低い (OR 0.26,P = .01).
結論:
- 体重過多/肥満の個体において,血清25OH) D濃度と重度のMASLDの間には,有意な逆の関連性がある.
- 低ビタミンDレベルは肝臓脂肪と皮下脂肪の増加と関連しています
- 基礎となる代謝機構と肝臓の保護に対する潜在的な治療効果を明らかにするために,さらなる研究が必要である.
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