関連する実験動画

Updated: Sep 9, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

538

PD-1抗体-薬物結合体およびその抗腫瘍メカニズムによるがん免疫療法の革新

Jianwei Wang1, Zeyu Chen2, Yanling Wu3

  • 1Lab of Drug Design and Synthesis, College of Pharmaceutical Science, Zhejiang University of Technology, Deqing 313299, China; Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Deqing 313299, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 30, 2025
PubMed
まとめ

プログラムされた死-1 (PD-1) を標的とする新型抗体-薬物結合剤 (ADC) は,がん免疫療法に対する二重アプローチを提供します. これらのPD-1ADCはT細胞の枯渇を逆転させ,細胞毒物質を直接腫瘍に投与し,免疫反応を強化し,抵抗を克服します.

キーワード:
抗体-薬物結合体ガンに対する免疫療法薬剤耐性免疫チェックポイントの封鎖PD-1 について

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